Table 29.1 Studies done in animal models to investigate the hepatoprotective actions of bioactive compounds isolated from different plant species

Plant spp. used

Dose (mg/kg), admin.

route

Animal models

Possible mechanism of action

Reference

Allium sativum

300 mg/kg for

14 days, i.p.

Male Wistar rats, D-galactosamine and

lipopolysaccharide (DGaIN/LPS)-

induced hepatotoxicity

Antioxidant defence system

El-Beshbishy (2008)

Allium hirtifolium

0.1 and 1 g/kg, i.p.

Wistar rats, alloxan-induced diabetes

and liver damage

By the reduction of liver cell damage and

also through hypoglycaemic and

hypolipidaemic activities and thereby

preventing fatty liver formation

Kazemi et al. (2010)

Andrographis

paniculata

100 mg/kg, i.p.

Wistar rats, CCl4-induced

hepatotoxicity

By decreasing the oxidative stress

Handa and Sharma

(1990)

Apium graveolens

200 mg/kg p.o.

Porton albino rats, paracetamol and

thioacetamide-induced hepatotoxicity

Might be due to activation of

reticuloendothelial system functions or

inhibition of protein biosynthesis

Singh and Handa

(1995)

Hygrophila

auriculata

200 mg/kg p.o.

Porton albino rats, paracetamol and

thioacetamide-induced hepatotoxicity

Might be due to activation of

reticuloendothelial system functions or

inhibition of protein biosynthesis

Singh and Handa

(1995)

Asparagus

racemosus

150 and 300 mg/kg, s.

c.

Wistar rats, CCl4-induced

hepatotoxicity

Due to antioxidant activity of flavonoids

Acharya et al. (2012)

Berberis vulgaris

(berberine)

80, 120 and 160 mg/

kg, orally

Male Sprague-Dawley rats, CCl4-

induced acute liver damage

Not known

Feng et al. (2010)

Boerhaavia

diffusa

2 mLkg, orally

Male albino rats, thioacetamide-

induced hepatotoxicity

Membrane stabilising effects

Rawat et al. (1997)

Crocus sativus

20 mg/kg, orally

Male Wistar rats, acetyl-para-

aminophenol (APAP)-induced

hepatotoxicity

Might be due to the presence of flavonoids

and their antioxidant properties

Omidi et al. (2014)

Curcuma longa

250 and 500 mg/kg,

orally

Sprague Dawley rats, thioacetamide-

induced hepatotoxicity

Might be due to direct antioxidant and free

radical scavenging mechanisms

Salama et al. (2013)

(continued)

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